Doxycycline is contraindicated in children under 12 years old due to potential effects on teeth and bones. Which statement best reflects this?

• A. Doxycycline is safe for children under 12
• B. Doxycycline should be avoided in children under 12
• C. Doxycycline is preferred in pediatric Lyme disease
• D. Doxycycline has no impact on dental development in children

Answer: (B)

Doxycycline is a tetracycline, and in developing children it can bind calcium in teeth and bones. This can lead to permanent tooth discoloration and potential enamel defects, as well as effects on bone growth during periods of development. Because of this, doxycycline is generally avoided in kids under about 12 years old, and clinicians choose safer alternatives for common pediatric infections. The statement that it should be avoided in children under 12 captures this safety concern. The other options either imply safety, preference for use, or deny any dental impact, which conflicts with the known risk of tooth discoloration with tetracyclines in developing children.