Rho-Gam is indicated for an unsensitized Rh-negative mother following which scenarios?

• A. A spontaneous abortion in an AB-negative mother
• B. An Rh-negative mother with an Rh-negative infant
• C. An AB-positive mother with a spontaneous abortion
• D. An AB-negative mother with a spontaneous abortion

Answer: (D)

RhoGAM is given to an unsensitized Rh-negative mother after events that can let fetal Rh-positive red cells enter maternal circulation, to prevent the mother from forming anti-D antibodies. A spontaneous abortion is one such event where fetomaternal hemorrhage can occur, so prophylaxis is recommended to avoid sensitization. The decision isn’t about ABO status or the exact ABO type of the infant; it’s about the risk of exposure to Rh-positive fetal cells. If the mother isRh-positive, or if there is certainty that the fetus is Rh-negative, RhoGAM isn’t indicated. Therefore, in an unsensitized Rh-negative mother following a spontaneous abortion, RhoGAM is appropriately given.