What is the mechanism of action of infliximab (Remicade)?

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Multiple Choice

What is the mechanism of action of infliximab (Remicade)?

Explanation:
Infliximab works by being a monoclonal antibody that targets tumor necrosis factor-alpha (TNF-α), a key inflammatory cytokine. By binding TNF-α, it blocks its interaction with TNF receptors on cells, which stops the inflammatory signaling cascade and reduces the production of other proinflammatory mediators. This neutralization can also lead to the destruction of TNF-expressing immune cells via immune mechanisms like antibody-dependent cellular cytotoxicity. It is not about blocking lymphocyte proliferation, it does not have a direct effect on smooth muscle, and it is not a serotonin (5-HT) antagonist.

Infliximab works by being a monoclonal antibody that targets tumor necrosis factor-alpha (TNF-α), a key inflammatory cytokine. By binding TNF-α, it blocks its interaction with TNF receptors on cells, which stops the inflammatory signaling cascade and reduces the production of other proinflammatory mediators. This neutralization can also lead to the destruction of TNF-expressing immune cells via immune mechanisms like antibody-dependent cellular cytotoxicity. It is not about blocking lymphocyte proliferation, it does not have a direct effect on smooth muscle, and it is not a serotonin (5-HT) antagonist.

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