Which disease presents with a 'slapped cheek' rash on the face in children?

• A. Scarlet fever
• B. Rubella
• C. Roseola
• D. Erythema infectiosum

Answer: (D)

Classic facial “slapped cheek” rash in children points to erythema infectiosum (fifth disease) caused by Parvovirus B19. The hallmark is a bright red rash on the cheeks that gives a sunburned, slapped appearance, often followed days later by a lacy, reticular rash on the trunk and extremities. Before the rash appears, there may be mild fever or malaise, and the infection is contagious via respiratory droplets. In some individuals, especially those with hemolytic disorders, Parvovirus B19 can cause a temporary aplastic crisis; in pregnancy, it can pose risks to the fetus. This pattern helps distinguish it from other common exanthems: scarlet fever has a fine, sandpaper-like rash with fever and circumoral pallor; rubella presents with a face-first maculopapular rash and postauricular lymphadenopathy; roseola starts with high fever that resolves before a trunk-oriented rash appears.